On the 11th April 1988 the school started with twenty nine (29) students and ten (10) staff with Sr. Maria Ngozi Ajelu HHCJ (RIP) as the pioneer Principal and sister Jane Theresa Njoku HHCJ as the Vice Principal.
At inception the school was known and called Handmaids Mater Dei Professional Institute, Obube but was later changed to Handmaids Mater Dei Secondary School on the 16th September 2002 as a fully fledged secondary school.
The following sisters have served as Principals:
- Sister Maria Ngozi Ajelu HHCJ
- Justina Udebunjo HHCJ
- Patricia Osineme HHCJ
- Catherine Dioka HHCJ
- Delphine F. Ozoigbo HHCJ
- Domnia Okere HHCJ
- Philomena Madu HHCJ (Incumbent Principal)